New asthma research reveals a potential breakthrough in the treatment approach.

British scientists have identified a previously unknown mechanism contributing to the damage caused by asthma, suggesting a novel strategy for intervention.

The research, conducted at King’s College London and published in the journal Science, indicates that during asthma attacks, cells lining the airways are subjected to destructive squeezing forces, exacerbating the condition.

Traditionally, asthma treatment has focused on managing inflammation and maintaining airway openness. However, this study suggests that targeting the cellular damage occurring during attacks could disrupt the harmful cycle of inflammation, tissue repair, and recurrent infections.

Professor Jody Rosenblatt, the lead researcher, emphasised the importance of the airway lining as the body’s primary defence against infections, highlighting the need to protect it from damage during asthma episodes.

The researchers observed that bronchoconstriction, the tightening of smooth muscles around the airways, leads to significant harm to the airway lining. This damage perpetuates long-term inflammation and susceptibility to infections, perpetuating the cycle of asthma exacerbations.

To address this issue, the team explored the potential of gadolinium, a chemical element, as a preventive treatment. Initial experiments in mice showed promising results, but extensive research is required to assess its safety and efficacy in humans, a process that could take years.

Dr. Samantha Walker, Research and Innovation Director at Asthma and Lung UK, hailed the discovery as a significant step forward in asthma treatment. She emphasised the urgent need for new therapeutic options to improve outcomes for asthma patients, highlighting the importance of ongoing research funding.

Asthma affects over five million people in the UK, with symptoms ranging from coughing and wheezing to severe breathlessness during attacks. While existing treatments are effective for many, there remains a subset of patients for whom current therapies are inadequate.

Walker urged individuals with asthma to adhere to their prescribed medications and seek medical advice if their symptoms persist or worsen. Prompt intervention is crucial during asthma attacks, and individuals should not hesitate to seek emergency assistance if their symptoms do not improve with their reliever inhaler or if the attack lasts longer than four hours.

In conclusion, the findings from this research offer hope for the development of more targeted and effective treatments for asthma, potentially transforming the lives of millions of patients worldwide.